Applying Biest cream at night ensures a 9-12 hour window from application to bloodwork, which provides the most accurate results. Avoid applying creams:
- Too close to your bloodwork, as it can cause artificially high readings.
- Too far in advance (e.g., 24 hours), as it may not reflect current levels.
For the best results, schedule your bloodwork in the morning, when hormone levels are naturally more stable.