Current evidence suggests yes, especially for certain hormones:
Bioidentical progesterone appears safer for breast tissue than synthetic progestins
Transdermal (skin) estrogen doesn’t increase blood clot risk like oral estrogen
Bioidentical hormones are molecularly identical to what your body produces

However, “bioidentical” doesn’t automatically mean “no risks.” Proper screening, appropriate dosing, and ongoing monitoring are essential regardless of hormone type.